SAMe????

Question:

I recently purchased the Nature Made brand of SAMe. The packaging says SAM-e (S-adenosylmethionine) 200mg . Does anyone know how much SAMe is actually contained in each tablet of this product? Roberto

The Nature Made product contains 200 mg SAM-e per tablet, in the form of approximately 380 mg SAM-e 1,4 butanedisulfonate. "Go, hang a salami; I’m a lasagna hog!"

Response:

– Hide quoted text — Show quoted text – treatment of various diseases. There is evidence about its efficacy for example in the treatment of depression, liver diseases, osteoarthritis, schizophrenia, demyelination diseases and dementia. For more details see web page Interesting. So SAM in it self has healing properties, not as a cofactor in enzymatic reactions?? Like methylating epinephrine or norepinephrine using COMT as an enzyme and Mg as a metal cofactor ? No, I haven’t read any speculation that SAMe works directly, at least as an antidepressant. The most popular hypothesis for its neuropsychiatric effects is that it works, as a methyl donor, by boosting serotonin synthesis and (if memory serves) by rejuvenating/"refluidizing" old neuronal membranes. SAM is a methyl donor in a long range of reactions and it is regenerated using folic acid and/or betaine via methionine from SAHc, S-adenosylhomocysteine. (COMT was the first enzyme I worked with as a biochemistry student) The lack of removing homocystein generated from SAM/SAH is thought to be an important reason for homocysteinuria, which may led into CVD. So maybe too high turnover of SAM into SAHc is also dangerous if folic acid or betaine is lacking in body. Not good. Yes. And with dosages as high as 1 or 2 grams a day of SAMe being prescribed (for depression at least), it would be foolish not to balance it with folic acid or, better yet, a good medium- to high-potency multivitamin/mineral supplement (maybe with some extra folate on the side). These additional nutrients – especially the folic acid – could be therapeutic for depression and dementia in their own right. This is quite correct and the same advice applies if you are taking extra methionine so that it will produce more SAM. The last thing that you want is to get CVD as a side effect of curing your depression! –Tom Tom Matthews Tom In the SAMe that is being sold in the US is only 48-52% SAMe in concentration. I think that many if not all manufacturers are using 200mg of this raw material and advertising it as 200mg SAMe even though they know it is only 50% which they sometimes put on the label as well. With these doses discussed It should be clarified which number to go by. I know lef.org sells SAMe which was the orginal european product, can you tell me how the amount in the product is calculated ? I recently purchased the Nature Made brand of SAMe. The packaging says SAM-e (S-adenosylmethionine) 200mg . Does anyone know how much SAMe is actually contained in each tablet of this product? Roberto

– Caroline Roberto, I called Nature Made at 800-276-2878 and asked the specific question "how much of the SAMe is actually in each tablet?". I was told that the ACTIVE ingredient in each tablet is ONLY S-adenosylmethionine or SAMe. The other ingredients listed on the side of the package sometimes called fillers are not included in this measurment.So,the serving size listed is for 2 tablets, which would be 400mg of SAMe. 1 tablet of SAMe would be 200mg.Hope this helps you. You might check out Mothernature.com. They have good prices for SAMe.

Response:

And what is the source of the SAMe? is there any animal sources in SAMe? Liselotte – Hide quoted text — Show quoted text – treatment of various diseases. There is evidence about its efficacy for example in the treatment of depression, liver diseases, osteoarthritis, schizophrenia, demyelination diseases and dementia. For more details see web page Interesting. So SAM in it self has healing properties, not as a cofactor in enzymatic reactions?? Like methylating epinephrine or norepinephrine using COMT as an enzyme and Mg as a metal cofactor ? No, I haven’t read any speculation that SAMe works directly, at least as an antidepressant. The most popular hypothesis for its neuropsychiatric effects is that it works, as a methyl donor, by boosting serotonin synthesis and (if memory serves) by rejuvenating/"refluidizing" old neuronal membranes. SAM is a methyl donor in a long range of reactions and it is regenerated using folic acid and/or betaine via methionine from SAHc, S-adenosylhomocysteine. (COMT was the first enzyme I worked with as a biochemistry student) The lack of removing homocystein generated from SAM/SAH is thought to be an important reason for homocysteinuria, which may led into CVD. So maybe too high turnover of SAM into SAHc is also dangerous if folic acid or betaine is lacking in body. Not good. Yes. And with dosages as high as 1 or 2 grams a day of SAMe being prescribed (for depression at least), it would be foolish not to balance it with folic acid or, better yet, a good medium- to high-potency multivitamin/mineral supplement (maybe with some extra folate on the side). These additional nutrients – especially the folic acid – could be therapeutic for depression and dementia in their own right. This is quite correct and the same advice applies if you are taking extra methionine so that it will produce more SAM. The last thing that you want is to get CVD as a side effect of curing your depression! –Tom Tom Matthews Tom In the SAMe that is being sold in the US is only 48-52% SAMe in concentration. I think that many if not all manufacturers are using 200mg of this raw material and advertising it as 200mg SAMe even though they know it is only 50% which they sometimes put on the label as well. With these doses discussed It should be clarified which number to go by. I know lef.org sells SAMe which was the orginal european product, can you tell me how the amount in the product is calculated ? I recently purchased the Nature Made brand of SAMe. The packaging says SAM-e (S-adenosylmethionine) 200mg . Does anyone know how much SAMe is actually contained in each tablet of this product? Roberto

Response:

- Hide quoted text — Show quoted text – treatment of various diseases. There is evidence about its efficacy for example in the treatment of depression, liver diseases, osteoarthritis, schizophrenia, demyelination diseases and dementia. For more details see web page Interesting. So SAM in it self has healing properties, not as a cofactor in enzymatic reactions?? Like methylating epinephrine or norepinephrine using COMT as an enzyme and Mg as a metal cofactor ? No, I haven’t read any speculation that SAMe works directly, at least as an antidepressant. The most popular hypothesis for its neuropsychiatric effects is that it works, as a methyl donor, by boosting serotonin synthesis and (if memory serves) by rejuvenating/"refluidizing" old neuronal membranes. SAM is a methyl donor in a long range of reactions and it is regenerated using folic acid and/or betaine via methionine from SAHc, S-adenosylhomocysteine. (COMT was the first enzyme I worked with as a biochemistry student) The lack of removing homocystein generated from SAM/SAH is thought to be an important reason for homocysteinuria, which may led into CVD. So maybe too high turnover of SAM into SAHc is also dangerous if folic acid or betaine is lacking in body. Not good. Yes. And with dosages as high as 1 or 2 grams a day of SAMe being prescribed (for depression at least), it would be foolish not to balance it with folic acid or, better yet, a good medium- to high-potency multivitamin/mineral supplement (maybe with some extra folate on the side). These additional nutrients – especially the folic acid – could be therapeutic for depression and dementia in their own right. This is quite correct and the same advice applies if you are taking extra methionine so that it will produce more SAM. The last thing that you want is to get CVD as a side effect of curing your depression! –Tom Tom Matthews Tom In the SAMe that is being sold in the US is only 48-52% SAMe in concentration. I think that many if not all manufacturers are using 200mg of this raw material and advertising it as 200mg SAMe even though they know it is only 50% which they sometimes put on the label as well. With these doses discussed It should be clarified which number to go by. I know lef.org sells SAMe which was the orginal european product, can you tell me how the amount in the product is calculated ?

Response:

Tom In the SAMe that is being sold in the US is only 48-52% SAMe in concentration. I think that many if not all manufacturers are using 200mg of this raw material and advertising it as 200mg SAMe even though they know it is only 50% which they sometimes put on the label as well. With these doses discussed It should be clarified which number to go by. I know lef.org sells SAMe which was the orginal european product, can you tell me how the amount in the product is calculated ?

Response:

Alf, do you know anything about rates of promotion/inhibition/limiting factors concerning the conversion of methionine to SAM?

I’ll try to find such data when I’m finished with producing the raw print for the abstract book for the 8th European Nutrition Conference at Lillehammer, 17-19. june (by the way, have you sent registration papers for joining the conference ?? There are still places! But since it is after april 15., prices has increased a little. There are going to be several posters and oral presentations about folate. Alf Christophersen, Computer engineer University of Oslo Tel. +47 22 85 13 27, Fax: 22 85 15 32 URL: http://www.uio.no/~achristo

Response:

Alf, do you know anything about rates of promotion/inhibition/limiting factors concerning the conversion of methionine to SAM? I’ll try to find such data when I’m finished with producing the raw print for the abstract book for the 8th European Nutrition Conference at Lillehammer, 17-19. june (by the way, have you sent registration papers for joining the conference ?? There are still places! But since it is after april 15., prices has increased a little. There are going to be several posters and oral presentations about folate.

I would love to come, but decided early that a trip to Europe (and all the expense) is not for me right now. I have so much that I need to learn just from texts and visiting the library that going to conferences is less cost-time/productive at the moment. And in addition I am saving all my money to apply it to life extension research at the right time (when I amass enough to have a say in what is done). –Tom Tom Matthews The LIFE EXTENSION FOUNDATION – http://www.lef.org – 800-544-4440 A non-profit membership organization dedicated to the extension of the healthy human lifespan through ground breaking research, innovative ideas and practical methods. LIFE EXTENSION MAGAZINE – The ultimate source for new health and medical findings from around the world.

Response:

Yes, I am well aware of this practice with many nutrients – like selling 200 mg DMAE bitartrate capsules when the DMAE content is only 37% or 74 mg. On the LEF labeling and in the new product directory, special effort is being made to always make it clear precisely how much of the ‘active’ chemical is in the product. LEF’s SAM product currently says 200 mg of SAM. I will check to see if this is pure SAM or not. –Tom Tom Matthews The LIFE EXTENSION FOUNDATION – http://www.lef.org – 800-544-4440 A non-profit membership organization dedicated to the extension of the healthy human lifespan through ground breaking research, innovative ideas and practical methods. LIFE EXTENSION MAGAZINE – The ultimate source for new health and medical findings from around the world.

Response:

This is quite correct and the same advice applies if you are taking extra methionine so that it will produce more SAM. The last thing that you want is to get CVD as a side effect of curing your depression! –Tom Tom Matthews The LIFE EXTENSION FOUNDATION – http://www.lef.org – 800-544-4440 A non-profit membership organization dedicated to the extension of the healthy human lifespan through ground breaking research, innovative ideas and practical methods. LIFE EXTENSION MAGAZINE – The ultimate source for new health and medical findings from around the world.

Response:

I just received the following reply from Dayna Dye (LEF Advisor Manager and a dynamite, competent person): "I spoke with our supplier and he informed me that each tablet contains 400 mg of the salt of SAMe which provides 200 mg SAMe." –Tom Tom Matthews The LIFE EXTENSION FOUNDATION – http://www.lef.org – 800-544-4440 A non-profit membership organization dedicated to the extension of the healthy human lifespan through ground breaking research, innovative ideas and practical methods. LIFE EXTENSION MAGAZINE – The ultimate source for new health and medical findings from around the world.

Response:

so SAM should be taken with adequate amounts of of folic acid or betaine ? I thought that betaine made SAM ?

Betaine makes methionine, but in next step methionine will possibly be made into SAM, but not necessary. If betaine and/or folate is lacking, the SAHc made from SAM will build up as homocysteine if not enough is converted into cysteine. Alf Christophersen, Computer engineer University of Oslo Tel. +47 22 85 13 27, Fax: 22 85 15 32 URL: http://www.uio.no/~achristo

Response:

So betaine and folic acid are independent. Neither is required for the other’s action.

Seems not to be that simple Sheils & Young has a long chapter on this and they state that often both are lacking. It is postulated (have not time to find if it is proven) that folate is needed for betaine production. So folate deficiency will also produce betaine deficiency in the end. By eating members of the Beta family (red beets etc.) grown in salt-rich soil, you may have a good dietary source of betaine. It is an anti-salt stress agent in Beta sp., but is only present under that stress. It is not induced when growing Beta sp. in normal soil. Salt-stressed Beta is the only known dietary source of betain (who has derived its name from Beta) Alf Christophersen, Computer engineer University of Oslo Tel. +47 22 85 13 27, Fax: 22 85 15 32 URL: http://www.uio.no/~achristo

Response:

Since that is about the last thing a layman eating all types of pure amino acids just because he thinks it is good for his body, do know about, it is why selling pure amino acids is strictly forbidden in many countries, at least not without a prescription which you very seldom gets. Methionine is only one of many amino acids with toxic side effects if taking too much of. Alf Christophersen, Computer engineer University of Oslo Tel. +47 22 85 13 27, Fax: 22 85 15 32 URL: http://www.uio.no/~achristo

Response:

so SAM should be taken with adequate amounts of of folic acid or betaine ? I thought that betaine made SAM ? Betaine makes methionine,

Since the betaine only supplies the methyl group of a much larger molecule (supplied by homocysteine), I think it is not correct to say that ‘betaine *makes* methione’. It would be better to said betaine is a ‘cofactor’, or simply that betaine is one molecule which can supply the necessary methyl group to convert homocysteine into methionine. but in next step methionine will possibly be made into SAM, but not necessary.

Alf, do you know anything about rates of promotion/inhibition/limiting factors concerning the conversion of methionine to SAM? If betaine and/or folate is lacking, the SAHc made from SAM will build up as homocysteine if not enough is converted into cysteine.

Certainly that is the danger. –Tom Tom Matthews The LIFE EXTENSION FOUNDATION – http://www.lef.org – 800-544-4440 A non-profit membership organization dedicated to the extension of the healthy human lifespan through ground breaking research, innovative ideas and practical methods. LIFE EXTENSION MAGAZINE – The ultimate source for new health and medical findings from around the world.

Response:

So betaine and folic acid are independent. Neither is required for the other’s action. Seems not to be that simple Sheils & Young has a long chapter on this and they state that often both are lacking. It is postulated (have not time to find if it is proven) that folate is needed for betaine production. So folate deficiency will also produce betaine deficiency in the end.

Of course, if we go backwards, we will find many other nutrients that are necessary both for production of betaine and THF (the active form of folic acid). In fact, from what I understand, so little betaine is produced by the body normally that the betaine conversion pathway is considered insignificant wrt the folate pathway. That is why I was assuming that one is supplementing betaine here, otherwise there is little point is discussing the betaine pathway. By eating members of the Beta family (red beets etc.) grown in salt-rich soil, you may have a good dietary source of betaine. It is an anti-salt stress agent in Beta sp., but is only present under that stress. It is not induced when growing Beta sp. in normal soil. Salt-stressed Beta is the only known dietary source of betain (who has derived its name from Beta)

–Tom Tom Matthews The LIFE EXTENSION FOUNDATION – http://www.lef.org – 800-544-4440 A non-profit membership organization dedicated to the extension of the healthy human lifespan through ground breaking research, innovative ideas and practical methods. LIFE EXTENSION MAGAZINE – The ultimate source for new health and medical findings from around the world.

Response:

so SAM should be taken with adequate amounts of of folic acid or betaine ? I thought that betaine made SAM ?

Response:

treatment of various diseases. There is evidence about its efficacy for example in the treatment of depression, liver diseases, osteoarthritis, schizophrenia, demyelination diseases and dementia. For more details see web page Interesting. So SAM in it self has healing properties, not as a cofactor in enzymatic reactions?? Like methylating epinephrine or norepinephrine using COMT as an enzyme and Mg as a metal cofactor ?

No, I haven’t read any speculation that SAMe works directly, at least as an antidepressant. The most popular hypothesis for its neuropsychiatric effects is that it works, as a methyl donor, by boosting serotonin synthesis and (if memory serves) by rejuvenating/"refluidizing" old neuronal membranes. SAM is a methyl donor in a long range of reactions and it is regenerated using folic acid and/or betaine via methionine from SAHc, S-adenosylhomocysteine. (COMT was the first enzyme I worked with as a biochemistry student) The lack of removing homocystein generated from SAM/SAH is thought to be an important reason for homocysteinuria, which may led into CVD. So maybe too high turnover of SAM into SAHc is also dangerous if folic acid or betaine is lacking in body. Not good.

Yes. And with dosages as high as 1 or 2 grams a day of SAMe being prescribed (for depression at least), it would be foolish not to balance it with folic acid or, better yet, a good medium- to high-potency multivitamin/mineral supplement (maybe with some extra folate on the side). These additional nutrients – especially the folic acid – could be therapeutic for depression and dementia in their own right. Syd Alf Christophersen, Computer engineer University of Oslo Tel. +47 22 85 13 27, Fax: 22 85 15 32 URL: http://www.uio.no/~achristo

http://www.escape.ca/~sgb Dealing with Depression Naturally and other books by Syd Baumel. …and cool record reviews!

Response:

SAM is produced from methionine. Betaine (trimethylglycine – TMG) and folate/B6/B12 are only necessary to convert homocysteine to methionine and complete the cycle which begins after SAM gives up a methyl group (thereby serving its major systemic function). There are two independent pathways between homocysteine and methionine. One it a very straightforward one where TMG gives up a methyl group to become DMG and the methyl group added to homocysteine by an enzyme produces methionine. The other pathway involves donation of a methyl group by methyltetrahydrofolate with B12 as a coenzyme and then the regeneration of MethylTHF by the actions of B6 and FAD (a riboflavin dependent enyme). So betaine and folic acid are independent. Neither is required for the other’s action. –Tom Tom Matthews The LIFE EXTENSION FOUNDATION – http://www.lef.org – 800-544-4440 A non-profit membership organization dedicated to the extension of the healthy human lifespan through ground breaking research, innovative ideas and practical methods. LIFE EXTENSION MAGAZINE – The ultimate source for new health and medical findings from around the world.

Response:

Wow now that is a good post ! thanks Matti, it would take some people days to compile this complete of a list – Hide quoted text — Show quoted text – Does anyone know what SAMe is? SAMe is S-adenosyl-l-methionine, a substance which occurs naturally in the human body. It can de regarded as a kind of "alertness hormone", whose level is high during the day when melatonin level is low, and low during the night when melatonin level is high. SAMe has been researched for the treatment of various diseases. There is evidence about its efficacy for example in the treatment of depression, liver diseases, osteoarthritis, schizophrenia, demyelination diseases and dementia. For more details see web page S-Adenosylmethionine (SAMe). Part1. An Exciting New Antiaging Therapy http://lef.org/magazine/mag97/march97-report.html I think that SAMe is currently best known as a new promising OTC antidepressant. See the news article New supplement lauded for treating depression. Thursday, April 15, 1999, Miami Herald http://www.herald.com:80/content/today/living/health/digdocs/087259.htm SAMe is a part of LEF’s depression protocol on the web page http://lef.org/protocols/prtcl-040.shtml Other SAMe web links http://www.inetcorp.net.mx/cimar/adenosyl.html http://www.antiaging-systems.com/aama2z.htm http://www.antiaging-systems.com/bulletins.htm#MAY 1998 http://lef.org/prod_desc/item120.html http://lef.org/magazine/hotlines.html http://lef.org/protocols/abstracts/abstr-040.html http://lef.org/shop/march-abs97.html http://lef.org/shop/april-abst97.html http://lef.org/magazine/mag97/sept97-abs.html S-Adenosylmethionine (SAMe). Part 2: Fast-Acting Natural Antidepressant http://lef.org/cgi-local/shop.pl/page=april-report97.html SAMe Part 3: The Liver SuperNutrient http://lef.org/cgi-local/shop.pl/page=june-report972.html SAMe Part 4: Treatment for Arthritis http://lef.org/magazine/mag97/sept97-report.html Selected MedLine references about SAMe S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies. Bressa GM. Department of Psychiatry, University Cattolica Sacro Cuore School of Medicine, Rome, Italy. Acta Neurol Scand Suppl 1994;154:7-14 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7941964&form=… Parenteral S-adenosyl-methionine (SAMe) in depression: literature review and preliminary data. Janicak PG, Lipinski J, Davis JM, Altman E, Sharma RP. Psychopharmacol Bull. 1989;25(2):238-42. S-adenosylmethionine in depression. A literature review and preliminary report.Janicak PG, Lipinski J, Davis JM, Comaty JE, Waternaux C, Cohen B, Altman E, Sharma RP. Ala J Med Sci. 1988 Jul;25(3):306-13. Review. [S-Adenosyl-L-methionine. Latest results on its efficacy as an antidepressive agent]. Ortiz P. Actas Luso Esp Neurol Psiquiatr Cienc Afines. 1988 May-Jun;16(3):201-3. S-adenosylmethionine in the treatment of depression. Vahora SA, Malek-Ahmadi P. Texas Tech University, School of Medicine, Department of Psychiatry, Lubbock 79430. Neurosci Biobehav Rev 1988 Summer;12(2):139-41 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3050630&form=… [Therapeutic indications of S-adenosyl methionine in neuropsychiatry]. [Article in French]. Tramoni AV, Azorin JM. Clinique de Psychiatrie et de Psychologie Medicale, C.H.U. Timone, Marseille. Encephale 1988 May-Jun;14(3):113-8 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2900133&form=… Neuropharmacology of S-adenosyl-L-methionine. Baldessarini RJ. Am J Med. 1987 Nov 20;83(5A):95-103. Review. S-adenosylmethionine in the treatment of osteoarthritis. Review of the clinical studies. di Padova C. Clinical Research Department, BioResearch S.p.A., Liscate-Milan, Italy. Am J Med. 1987 Nov 20;83(5A):60-5. Neuropharmacology of S-adenosyl methionine. Carney MW Clin Neuropharmacol. 1986;9(3):235-43. Review. The clinical potential of ademetionine (S-adenosylmethionine) in neurological disorders. Bottiglieri T, Hyland K, Reynolds EH. Metabolic Disease Center, Baylor Research Institute, Dallas, Texas. Drugs 1994 Aug;48(2):137-52 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7527320&form=… S-adenosylmethionine levels in psychiatric and neurological disorders: a review. Bottiglieri T, Hyland K. Metabolic Disease Center, Baylor Research Institute, Dallas, TX 75226. Acta Neurol Scand Suppl 1994;154:19-26 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7524260&form=… [Ademetionine: the state of the art and future prospects]. [Article in Italian] Almasio P, Pagliaro L Clinica Medica R, Universita degli Studi di Palermo. Ann Ital Med Int 1993 Oct;8 Suppl:52S-55S http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8117523&form=… Review article: S-adenosyl-L-methionine–a new therapeutic agent in liver disease? Osman E, Owen JS, Burroughs AK. University Department of Medicine, Royal Free Hospital and School of Medicine, London, UK. Aliment Pharmacol Ther 1993 Feb;7(1):21-8 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8439634&form=… [S-adenosyl-L-methionine (SAMe) and its use in hepatology]. [Article in Italian]. Frezza M, Terpin MM, Peri A Servizio di Gastroenterologia ed Endoscopia Digestiva, Ospedale di Cattinara, Trieste. Minerva Gastroenterol Dietol 1992 Jul-Sep;38(3):145-51 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1299337&form=… Biochemistry and pharmacology of S-adenosyl-L-methionine and rationale for its use in liver disease. Chawla RK, Bonkovsky HL, Galambos JT Department of Medicine, Emory University School of Medicine, Atlanta, Georgia. Drugs 1990;40 Suppl 3:98-110 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2081485&form=… Affective disorders and S-adenosylmethionine: a new hypothesis. Cantoni GL, Mudd SH, Andreoli V. Trends Neurosci 1989 Sep;12(9):319-24 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2480671&form=… S-adenosyl-L-methionine. A review of its pharmacological properties and therapeutic potential in liver dysfunction and affective disorders in relation to its physiological role in cell metabolism. Friedel HA, Goa KL, Benfield P. ADIS Drug Information Services, Auckland, New Zealand. Drugs 1989 Sep;38(3):389-416 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2680435&form=… — Matti Narkia

Response:

Hi All, Does anyone know what SAMe is?

S-Adenosylmethionine. Alf Christophersen, Computer engineer University of Oslo Tel. +47 22 85 13 27, Fax: 22 85 15 32 URL: http://www.uio.no/~achristo

Response:

Does anyone know what SAMe is?

SAMe is S-adenosyl-l-methionine, a substance which occurs naturally in the human body. It can de regarded as a kind of "alertness hormone", whose level is high during the day when melatonin level is low, and low during the night when melatonin level is high. SAMe has been researched for the treatment of various diseases. There is evidence about its efficacy for example in the treatment of depression, liver diseases, osteoarthritis, schizophrenia, demyelination diseases and dementia. For more details see web page S-Adenosylmethionine (SAMe). Part1. An Exciting New Antiaging Therapy http://lef.org/magazine/mag97/march97-report.html I think that SAMe is currently best known as a new promising OTC antidepressant. See the news article New supplement lauded for treating depression. Thursday, April 15, 1999, Miami Herald http://www.herald.com:80/content/today/living/health/digdocs/087259.htm SAMe is a part of LEF’s depression protocol on the web page http://lef.org/protocols/prtcl-040.shtml Other SAMe web links http://www.inetcorp.net.mx/cimar/adenosyl.html http://www.antiaging-systems.com/aama2z.htm http://www.antiaging-systems.com/bulletins.htm#MAY 1998 http://lef.org/prod_desc/item120.html http://lef.org/magazine/hotlines.html http://lef.org/protocols/abstracts/abstr-040.html http://lef.org/shop/march-abs97.html http://lef.org/shop/april-abst97.html http://lef.org/magazine/mag97/sept97-abs.html S-Adenosylmethionine (SAMe). Part 2: Fast-Acting Natural Antidepressant http://lef.org/cgi-local/shop.pl/page=april-report97.html SAMe Part 3: The Liver SuperNutrient http://lef.org/cgi-local/shop.pl/page=june-report972.html SAMe Part 4: Treatment for Arthritis http://lef.org/magazine/mag97/sept97-report.html Selected MedLine references about SAMe S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies. Bressa GM. Department of Psychiatry, University Cattolica Sacro Cuore School of Medicine, Rome, Italy. Acta Neurol Scand Suppl 1994;154:7-14 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7941964&form=… Parenteral S-adenosyl-methionine (SAMe) in depression: literature review and preliminary data. Janicak PG, Lipinski J, Davis JM, Altman E, Sharma RP. Psychopharmacol Bull. 1989;25(2):238-42. S-adenosylmethionine in depression. A literature review and preliminary report.Janicak PG, Lipinski J, Davis JM, Comaty JE, Waternaux C, Cohen B, Altman E, Sharma RP. Ala J Med Sci. 1988 Jul;25(3):306-13. Review. [S-Adenosyl-L-methionine. Latest results on its efficacy as an antidepressive agent]. Ortiz P. Actas Luso Esp Neurol Psiquiatr Cienc Afines. 1988 May-Jun;16(3):201-3. S-adenosylmethionine in the treatment of depression. Vahora SA, Malek-Ahmadi P. Texas Tech University, School of Medicine, Department of Psychiatry, Lubbock 79430. Neurosci Biobehav Rev 1988 Summer;12(2):139-41 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3050630&form=… [Therapeutic indications of S-adenosyl methionine in neuropsychiatry]. [Article in French]. Tramoni AV, Azorin JM. Clinique de Psychiatrie et de Psychologie Medicale, C.H.U. Timone, Marseille. Encephale 1988 May-Jun;14(3):113-8 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2900133&form=… Neuropharmacology of S-adenosyl-L-methionine. Baldessarini RJ. Am J Med. 1987 Nov 20;83(5A):95-103. Review. S-adenosylmethionine in the treatment of osteoarthritis. Review of the clinical studies. di Padova C. Clinical Research Department, BioResearch S.p.A., Liscate-Milan, Italy. Am J Med. 1987 Nov 20;83(5A):60-5. Neuropharmacology of S-adenosyl methionine. Carney MW Clin Neuropharmacol. 1986;9(3):235-43. Review. The clinical potential of ademetionine (S-adenosylmethionine) in neurological disorders. Bottiglieri T, Hyland K, Reynolds EH. Metabolic Disease Center, Baylor Research Institute, Dallas, Texas. Drugs 1994 Aug;48(2):137-52 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7527320&form=… S-adenosylmethionine levels in psychiatric and neurological disorders: a review. Bottiglieri T, Hyland K. Metabolic Disease Center, Baylor Research Institute, Dallas, TX 75226. Acta Neurol Scand Suppl 1994;154:19-26 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7524260&form=… [Ademetionine: the state of the art and future prospects]. [Article in Italian] Almasio P, Pagliaro L Clinica Medica R, Universita degli Studi di Palermo. Ann Ital Med Int 1993 Oct;8 Suppl:52S-55S http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8117523&form=… Review article: S-adenosyl-L-methionine–a new therapeutic agent in liver disease? Osman E, Owen JS, Burroughs AK. University Department of Medicine, Royal Free Hospital and School of Medicine, London, UK. Aliment Pharmacol Ther 1993 Feb;7(1):21-8 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8439634&form=… [S-adenosyl-L-methionine (SAMe) and its use in hepatology]. [Article in Italian]. Frezza M, Terpin MM, Peri A Servizio di Gastroenterologia ed Endoscopia Digestiva, Ospedale di Cattinara, Trieste. Minerva Gastroenterol Dietol 1992 Jul-Sep;38(3):145-51 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1299337&form=… Biochemistry and pharmacology of S-adenosyl-L-methionine and rationale for its use in liver disease. Chawla RK, Bonkovsky HL, Galambos JT Department of Medicine, Emory University School of Medicine, Atlanta, Georgia. Drugs 1990;40 Suppl 3:98-110 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2081485&form=… Affective disorders and S-adenosylmethionine: a new hypothesis. Cantoni GL, Mudd SH, Andreoli V. Trends Neurosci 1989 Sep;12(9):319-24 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2480671&form=… S-adenosyl-L-methionine. A review of its pharmacological properties and therapeutic potential in liver dysfunction and affective disorders in relation to its physiological role in cell metabolism. Friedel HA, Goa KL, Benfield P. ADIS Drug Information Services, Auckland, New Zealand. Drugs 1989 Sep;38(3):389-416 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2680435&form=… — Matti Narkia

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Hi All, Does anyone know what SAMe is? Thanks, — Reach beyond your grasp!

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