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absorption principles

Question:

I’m on their list as a potential testee.   Study is being run by Pfizer, should start about November.   They weren’t giving out any more details.

This will be Phase 3 of their inhaled insulin study (for some details, you can look on Inahle’s web site (www.inhale.com) for images of the inhaler, and the current status of various trials that are taking place around the US. One very common misconception of this device is that it will totally eliminate your need for injections.  This is not the case.  Everyone on the study will still need to take one evening injection of a long term insulin. I won’t rehash my earlier comments, suffice it to say that if you are interested, you can read my earlier comments through dejanews (just search for my unaltered email address), with regards to the use of "Inhaled Insulin." -bt

Response:

You know I just saw on tonites evening news, I watch NBC so it must have been there……. That they are doing a study now using an inhaler for insulin. It comes in a thingy like asthmatics use with a cartridge in it,  the bubble pack is exploded and you breath the insulin down into your lungs. Waaaala……no more shots. They put up a 1-800 if anyone wanted to try it out. You know, in the interest of science….(guinea pig) lol.

Part of my bachelor party was spent shooting paint pellets at a guy working on this: his estimates are very optimistic, I have my doubts. —                                 Nico Kadel-Garcia, ne’ Garcia <PGP is obviously a good idea: look at who objects to it.

Response:

I’m on their list as a potential testee.   Study is being run by Pfizer, should start about November.   They weren’t giving out any more details. — eeyore (Due to spam, my return address has been slightly altered.  Just take out the obvious.) Anee Bear wrote – Hide quoted text — Show quoted text – You know I just saw on tonites evening news, I watch NBC so it must have been there……. That they are doing a study now using an inhaler for insulin. It comes in a thingy like asthmatics use with a cartridge in it,  the bubble pack is exploded and you breath the insulin down into your lungs. Waaaala……no more shots. They put up a 1-800 if anyone wanted to try it out. You know, in the interest of science….(guinea pig) lol. Has anyone heard of this before…..or is it something that has been around and I am just now hearing about it? :) Anee "It is a mistake that there is no bath that will cure people’s manners, but drowning would help."                                Mark Twain

Response:

I personally find it quite credible that absorbtion occurs in the mouth and nasal passages. That is not in question for me, nor am I disputing that. Just, be careful about the accuracy of what is quoted as an authoritative source. Nanuq of the North Remove grzl to send email: I’m only a grizzly before (decaf) coffee!

You know I just saw on tonites evening news, I watch NBC so it must have been there……. That they are doing a study now using an inhaler for insulin. It comes in a thingy like asthmatics use with a cartridge in it,  the bubble pack is exploded and you breath the insulin down into your lungs. Waaaala……no more shots. They put up a 1-800 if anyone wanted to try it out. You know, in the interest of science….(guinea pig) lol. Has anyone heard of this before…..or is it something that has been around and I am just now hearing about it? :) Anee "It is a mistake that there is no bath that will cure people’s manners, but drowning would help."                                Mark Twain

Response:

First, I really, really don’t want to be part of the flame wars here between M Martin, Nico Garcia, & Joan. But (there’s always a but) two of the statements below deserve discussion. Here is an article that simplies explains a bit about oral and nasal absorption.  It would help to boost the theory that glucose can be absorbed thru the mouth, as well as the sublingual nitro pills.

[[snipped]] No one to my knowledge (I skipped a lot of the flame-laden posts) has even mentioned cocaine as a nasally and/or lingually absorbed drug. – Hide quoted text — Show quoted text – Oral absorption occurs when micro-sized beads or droplets of a drug or nutrient is taken into the body through the mouth or nose tissue. Blood capillaries are extremely close to the surface in these areas and readily absorb the nutrients or drugs into the blood stream. The flow is from this area of the mouth to the carotid artery and through the heart within seconds. Upon leaving the heart it should be totally dispensed throughout the body. The mucous membrane of the nose and mouth are the same. Anything administered in the nose can be taken by mouth with the same results or better. The mouth has a larger area for absorption and is thus preferred. The mouth is avoided by manufacturers due to the taste factor. It is much harder to make a pleasant tasting mouth spray than nasal. Sublingual is another method of limited oral absorption. When used as a liquid, this area under the tongue has great absorption powers but insufficient to consume the full liquid dose. Part of the dose is co-mingles when being dispersed under the tongue with saliva and carried into the stomach. Sublingual tablets or controlled dose is preferred for assured performance; e.g., sublingual nitroglycerin tablets for heart patients. The tablet is placed under the tongue and releases at a controlled rate allowing for full absorption. The results show that within seconds the nitroglycerin is working on the heart to restore normal rhythm.

To my knowledge, nitroglycerin is <not administered to restore heart <rythym. It is a fast acting, very strong vasodilator, restoring <flow to the heart by opening spasmed or partly blocked arteries to and from the heart. I’ve taken nitro. While it took care of my angina, I soon wished someone would surgically remove my head because it gave me a migraine that lasted 36 hours and that no pain reliever could touch. After several different ones were tried, I still had the migraine, I just didn’t care about the pain any more (la-la-la-la loopy). [[rest of the quoted article snipped]] But for any reputable medical/pharmaceutical company (since you didn’t cite the source, I deduce it is a company from the "products" shortcut, medical/pharmaceutical from the "Physician’s Desk Reference" shortcut at the bottom of your quote) to so misstate the purpose and action of such a basic, old time drug as sublingual nitroglycerin makes me wonder about the accuracy of the other statements. I personally find it quite credible that absorbtion occurs in the mouth and nasal passages. That is not in question for me, nor am I disputing that. Just, be careful about the accuracy of what is quoted as an authoritative source. — Nanuq of the North Remove grzl to send email: I’m only a grizzly before (decaf) coffee!

Response:

Here is an article that simplies explains a bit about oral and nasal absorption.  It would help to boost the theory that glucose can be absorbed thru the mouth, as well as the sublingual nitro pills. Ok Mr. Martin…have a field day responding. Oral absorption occurs when micro-sized beads or droplets of a drug or nutrient is taken into the body through the mouth or nose tissue. Blood capillaries are extremely close to the surface in these areas and readily absorb the nutrients or drugs into the blood stream. The flow is from this area of the mouth to the carotid artery and through the heart within seconds. Upon leaving the heart it should be totally dispensed throughout the body. The mucous membrane of the nose and mouth are the same. Anything administered in the nose can be taken by mouth with the same results or better. The mouth has a larger area for absorption and is thus preferred. The mouth is avoided by manufacturers due to the taste factor. It is much harder to make a pleasant tasting mouth spray than nasal. Sublingual is another method of limited oral absorption. When used as a liquid, this area under the tongue has great absorption powers but insufficient to consume the full liquid dose. Part of the dose is co-mingles when being dispersed under the tongue with saliva and carried into the stomach. Sublingual tablets or controlled dose is preferred for assured performance; e.g., sublingual nitroglycerin tablets for heart patients. The tablet is placed under the tongue and releases at a controlled rate allowing for full absorption. The results show that within seconds the nitroglycerin is working on the heart to restore normal rhythm. Had the tablet been swallowed, the heart wouldn’t have been affected. Nitroglycerin is now in a spray form for whole mouth absorption. A metered dose is sprayed in a puff throughout the mouth with predictable, accurate and effective results. When medication or nutrients are metered and sprayed over the entire surface of the mouth, oral absorption is at its best. Oral absorption is the preferred choice of medical experts for the administration of nutrients and drugs over the orally swallowed tablet or pill, thus avoiding the gastrointestinal tract and its many limitations. Oral absorption results in higher blood concentrates faster with more efficiency than the tablet or intramuscular injections. Tests from Massachusetts General Hospital have shown higher blood concentrates of insulin by spraying. The injections has taken 30 minutes longer to reach the same blood levels. "Medical procedures to obtain proper concentration of drugs or nutrients to be beneficial to the individual must be administered every 3 to 4 hours." "One larger or mega dose results in excessive or overdosing with taxation of the kidney to excrete. Comparative data — 100 mg. consumed as a tablet translates to a stabilized 8.3 mg. blood concentrate. 100 mg. consumed in 4 equal doses translates to a stable 78.6 mg. blood concentrate. Smaller doses administered with more frequency seem to raise blood concentrate." "Oral liquid or spray is far superior, showing higher concentration with lower more frequent dosages. Avoidance of gastrointestinal system is preferred when spray or sublingual is available." National Advisory Board [ Home | Products | Oral Absorption | Physicians Desk Reference | Request for Information ] Joan….

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